Copper Toxicity - Nutritional Disorders - Merck Manual Professional Edition
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Don’t fall for the copper‑toxicity scare, it’s misleading at best. True copper toxicity is extremely rare outside of genetic disorders like Wilson’s disease or Menkes syndrome. What’s more common is copper mismanagement- insufficient binding to ceruloplasmin, which renders copper bio‑unavailable, even when “levels” appear elevated. Factors like liver dysfunction, inflammation, and nutritional deficits (e.g. vitamin A) can lower ceruloplasmin, starving essential enzymes (like those for mitochondr
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