eLife2d
Stratification of enterochromaffin cells by single-cell expression analysis
Molecularly defined serotonin (enterochromaffin) cells of the gut lining were distinguished by single-cell expression analysis, in situ hybridization, and immunohistochemistry into 14 topographically ...
eLife2d
Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and biogenesis
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, China; Department of Molecular, Cellular, ...
eLife3d
Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan System Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, ...
eLife3d
The C3-C3aR axis modulates trained immunity in alveolar macrophages
Division of Pulmonary and Critical Care Medicine, John T. Milliken Department of Medicine, Washington University School of Medicine, St Louis, United States Division of Rheumatology, John T. Milliken ...
eLife3d
Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial
Kaplan–Meier curves showed that extended adjuvant pyrotinib administered after trastuzumab-based adjuvant therapy provides a promising survival benefit in patients with high-risk HER2-positive breast ...
eLife3d
Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models
A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...
eLife3d
A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids
This study presents an important finding on the molecular mechanism for transduction of environmentally induced polyphenism. The evidence supporting the claims of the author is solid. This paper would ...
eLife3d
Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models
Version of Record: This is the final version of the article. In Pech et al. the authors take advantage of a genetic model organism to investigate the convergent impact of multiple mutations linked to ...
eLife3d
Control of pili synthesis and putrescine homeostasis in Escherichia coli
Department of Biological Sciences, The University of Texas at Dallas, United States; Department of Urology, University of Texas Southwestern Medical Center, United States; ...
eLife3d
Neuroprotective role of Hippo signaling by microtubule stability control in Caenorhabditis elegans
Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Republic of Korea; ...
eLife3d
Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences
Using electrophysiological recordings in freely moving rats, this valuable study investigates the role of gamma oscillations in the development of spatial representations in the hippocampus.