Just 24 hours before their Week 15 matchup vs. the Tennessee Titans, the San Francisco 49ers got a concerning update on Christian McCaffrey.

As the 49ers prepare for Sunday’s matchup against the Tennessee Titans, McCaffrey’s availability has become a storyline. Earlier in the week, he battled an illness that limited his practice time, though he was able to log a full session on Friday.

Christian McCaffrey (back) has been added to the team's injury report and is listed as questionable for Sunday's game.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

San Francisco 49ers star running back Christian McCaffrey was added to the team's injury report Saturday due to a back injury. McCaffrey was listed as questionable for Sunday's game against the visiting Tennessee Titans.

The San Francisco 49ers on Saturday placed Brandon Aiyuk on the reserve/left squad list, ending his 2025 season and likely severing the team’s ties with the talented wide receiver for the future.

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.