An incident involving San Francisco 49ers star running back Christian McCaffrey led to a punishment from the NFL this weekend.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

An interesting Week 10 slate is set for Sunday, Nov. 9, and there are plenty of bets to consider across the board. Luckily, the SI Betting team has things narro

Asante Samuel Jr. to boost secondary after injuries. Analyst explains urgency, fit, and postseason Super Bowl impact.

DraftKings Sportsbook offers a $300 bonus and three free months of NBA League Pass, and you can use it to bet on Sunday's NFL schedule

You saw the mayhem. The Colts traded two first-round picks for a cornerback who’s been living off his rookie-year reputation for the past four seasons. The Cowboys coughed up a first and a second-rounder for a good player who is almost certainly going to stage a highly publicized mid-summer holdout for a new contract.

The San Francisco 49ers didn't make a trade at the NFL trade deadline, but head coach Kyle Shanahan said it wasn't for a lack of effort.

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -143 money line favorites (risk $143 to win $100),

A three-way tie at the top of one division by season’s end? One NFL writer has Mike Maconald’s Seahawks, along with the Rams and Niners, all finishing 12-5.

Brady is referencing the 49ers drafting quarterback Giovanni Carmazzi over him in the 2000 NFL Draft. He was selected in the third round, at pick 65, by the 49ers. He played just two seasons in San Francisco before leaving the NFL less than two years after being drafted.