eLife1h
Somatic mutation rates scale with time not growth rate in long-lived tropical trees
Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
eLife20h
Study highlights complexity of menopausal hormone therapy’s impact on brain health
A large UK study finds that the effects of menopausal hormone therapy on female brain health might vary depending on the duration of use and history of gynaecological surgery.
eLife1d
Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language
Recent research has used large language models (LLMs) to study the neural basis of naturalistic language processing in the human brain. LLMs have rapidly grown in complexity, leading to improved ...
eLife1d
Membrane potential modulates ERK activity and cell proliferation
Department of Physiology, Division of Life Science, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan ...
eLife2d
Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions
Two-photon (2P) fluorescence imaging through gradient index (GRIN) lens-based endoscopes is fundamental to investigate the functional properties of neural populations in deep brain circuits. However, ...
eLife1d
Publishing with eLife: “authors have a lot of control in the publication process”
What do authors think about publishing in eLife’s model? We spoke with Meike van der Heijden to find out about her experience.
eLife2d
Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma
The study is a valuable addition to the field, showing how particulate matter may be acting via nociceptor neurons towards neutrophilic asthma exacerbations. The solid evidence for the role of a ...
eLife2d
Decisions: Tracking the evolution of a single choice
Measuring the activity of hundreds of neurons in macaque brains simultaneously provides further evidence that drift-diffusion dynamics underlie how decisions are made in the brain.
eLife2d
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing
Endocrine Neoplasia Translational Research Center, Division of Endocrinology, Diabetes and Metabolism, Chaim Sheba Medical Center, and Tel Aviv University Faculty of Medicine, Ramat Gan, Israel This ...
eLife2d
Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans
Membrane proteins are sorted to the plasma membrane (PM) via Golgi-dependent trafficking. However, our recent studies challenged the essentiality of Golgi in the biogenesis of specific transporters.
eLife5d
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...
eLife12d
Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse early embryos
This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...