Donovan Mitchell joked that a kid talked so much trash while playing the NBA 2K video game that it fueled his 46-point performance against the 76ers.

Donovan Mitchell scores a season-high 46 points as the Cleveland Cavaliers defeated the Philadelphia 76ers 132-121.

The Philadelphia 76ers and the Cleveland Cavaliers meet Wednesday at Rocket Arena in Cleveland, Ohio. Tip-off is scheduled for 7 p.m. ET.

The Cleveland Cavaliers and Philadelphia 76ers squared off in an Eastern Conference matchup, in what could be a potential playoff preview. Philadelphia was without Joel Embiid in the second game of a back-to-back,

Philadelphia 76ers. Guards Darius Garland and Sam Merrill and center Jarrett Allen could all return Wednesday night. Garland has yet to make his season debut after undergoing offseason toe surgery.

NBA players are masters at finding motivation wherever they can. Donovan Mitchell reminded us of this fact on Wednesday when he credited a kid who was heckling him during an online game of NBA 2K26 for inspiring his brilliant 46-point, eight-assist outing in the Cleveland Cavaliers ' 132-121 win over the Philadelphia 76ers .

Donovan Mitchell is cleared to play for the Cleveland Cavaliers against the Philadelphia 76ers on November 5, 2025, following a left hamstring injury. His return, after a 37-point performance, provides a significant boost as Cleveland aims to build momentum.

Josh Giddey’s powerful knock against the 76ers made him add several records to his elite career. Here are all the milestones he has generated.

The Philadelphia 76ers upgraded Jared McCain to probable for Tuesday's game against the Chicago Bulls, clearing the way for the second-year guard to make his season debut in a battle of the surprising teams tied for first place in the Eastern Conference.

Preview the Cleveland Cavaliers' NBA matchup with Philadelphia, including betting odds, tips, trends, and game information.

The 76ers’ collapse vs. the Bulls was literally unprecedented in NBA history. Philadelphia blew a 24-point lead to fall 113-111.