Activating lysosome biogenesis helps alleviate cellular senescence in progeria. Hutchinson-Gilford progeria syndrome (HGPS) ...

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, and approximately 90% of cases are caused by ...

New research has uncovered a mechanism for parents to pass down longevity, to their progeny, via changes to their lysosome metabolism.

Scientists studying tiny roundworms have uncovered how the secrets of a long life can be passed from parents to their ...

Aggregated tau can be passed between cells in tiny vesicles known as exosomes. Once these lipid bubbles are inside a new cell, how does tau escape them? In the January 8 Acta Neuropathologica, ...

Of the 20,000+ human genes, none has greater influence on late-onset Alzheimer’s disease than APOE. But why do certain variants of this lipid transporter protect the brain, while others endanger it? A ...

Explore the impact of lysosomal lipid recycling in a rare multi-organ disorder linked to the SPNS1 gene mutations.

Michael N. Trinh, Michael S. Brown, Joseph L. Goldstein, Jaeil Han, Gonçalo Vale, Jeffrey G. McDonald, Joachim Seemann, Joshua T. Mendell, Feiran Lu Proceedings of ...

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, ...