Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...

Randomized controlled trials remain the most effective tool in the pharmaceutical industry’s evidence-generation toolkit. They are crucial for demonstrating novel drugs' safety and efficacy, assessing ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Breakthrough Designation: Pivotal Trials Lack Randomization, Double-Blinding and Control Groups A review of all therapeutics receiving a breakthrough designation and approved from 2012 to 2017 found a ...

Questions remain concerning the rapidity of immune responses and the durability and safety of vaccines used to prevent Zaire Ebola virus disease. We conducted two randomized, placebo-controlled trials ...

When designing experiments, one is on the lookout for confounds. These are systematic, consistent differences between the experimental and the control conditions, differences that the experimenter is ...