Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular ...

The drug is approved for use in adults, and rarely, in some children. Allopurinol’s drug classification is a xanthine oxidase inhibitor. Allopurinol oral tablets are available in two strengths: 100 ...

Allopurinol is currently used as urate-lowering therapy in patients with gout. Findings suggesting that allopurinol-related toxicity is associated with impaired renal function have led to the ...

In separate randomized controlled trials, allopurinol had no significant effect on kidney function decline. Urate-lowering therapy with allopurinol, a xanthine oxidase inhibitor, does not appear to ...

The effects of allopurinol treatment on mortality among patients with gout remain uncertain, with a new meta-analysis finding conflicting results. In a systematic review of the literature that ...

WASHINGTON -- Allopurinol, a widely used treatment for lowering serum urate levels, does not appear to increase risk of kidney deterioration in gout patients with normal or near-normal kidney function ...

Please provide your email address to receive an email when new articles are posted on . “Very few published studies and data are available that provide any population-level comparative data of the ...

Trial subgroup analyses support the use of either allopurinol or febuxostat in patients with stage 3 CKD and gout. A prespecified analysis of the STOP-GOUT trial revealed that allopurinol has similar ...