Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical Research Institute (IRCM) and the Maisonneuve-Rosemont Hospital Research Center ...

The highly pleiotropic Notch signalling pathway functions to control cell-fate determination in nearly every tissue and organ by influencing differentiation, proliferation or apoptotic events. Notch ...

The notch signaling pathway plays a major role in regulating various cellular processes during development, therefore dysregulation of this pathway can lead to disease. This basic signaling pathway ...

Researchers have shown for the first time that the mechanical force produced by cell-cell interactions is critical for programming by the Notch signaling system. During formation of multi-cellular ...

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice. The study, led by researchers from NYU Grossman School of Medicine, ...

High rate of TRG1–2 and prolonged RFS with OXA/TOM and FU/LFA during preoperative pelvic RT in patients with poor prognosis locally advanced rectal cancer (LARC) No significant financial relationships ...

Type 2 diabetes typically originates in persons with obesity-induced insulin resistance, but the condition manifests clinically as hyperglycemia due to diminished capacity of beta cells to adapt by ...

The “Notch” signalling system causes cells to commit to a particular and life-long function, such as a heart cell. When scientists blocked the signal by genetic manipulation, they found the cell could ...