I njuries are already biting the San Francisco 49ers after two of their top players were dinged up last week in the season-opening win over the Seattle Seahawks, yet the Niners are still 3-point favorites in Week 2 as they visit the New Orleans Saints.

Florio’s pick: Cowboys 23, Giants 13. Simms’s pick: Cowboys 28, Giants 17. From 15-2 in the 2024 regular season to 0-2 between the 2024 postseason and Week 1. The Lions are experiencing the growing pains of a team that is learning how to be a winner.

Playing in a confidence pool and looking for advice? KC Joyner has you covered with Week 2 picks straight up and against the spread.

The NFL is back in full swing with Week 2 of the season underway and a Sunday slate full of action on tap. If you're looking to spice up your viewing experience on Sunday with some NFL betting, we've created a three-leg parlay at Caesars Sportsbook featuring player props for three of the league's top running backs -- Derrick Henry of the Baltimore Ravens,

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