The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks its since inception. The model went 33-17 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

On the offensive side of the ball, the Bills have been a top-five unit, ranking best in the NFL by averaging 497.0 yards per game. The Broncos sport the best defense in the NFL with only 133.0 total yards allowed per game.

An all-encompassing look at the matchups to exploit or avoid and lineup locks in fantasy, as well as projected scores for all NFL games.

Ricky Pearsall is in line to be the 49ers' top wideout for Week 2 while Drake Maye is poised for a bounce-back performance versus Miami.

The NFL Week 2 schedule is headlined by a Super Bowl rematch between the Philadelphia Eagles and Kansas City Chiefs on Sept. 14. Eagles-Chiefs is the FOX late-afternoon national game on Sunday, the lone 3:25 p.m. CT game.

Aside from the Eagles-Chiefs rematch, the league is still buzzing over J.J. McCarthy, Daniel Jones and more heading into Week 2.

The Bucs are looking to make it two straight to open the 2025 campaign after narrowly beating the Falcons in Atlanta last week, 23-20. Rookie WR Emeka Egbuka caught his first two touchdown passes in the NFL and finished with four catches for 67 yards.

In a post on X, Madden highlighted adjustments to Philadelphia Eagles quarterback Jalen Hurts, Baltimore Ravens safety Kyle Hamilton, Seattle Seahawks wide receiver Jaxon Smith-Njigba and Washington Commanders rookie running back Jacory Croskey-Merritt:

Injuries are an unfortunate but continuous storyline in the NFL, and Week 2 is no exception. Already, the injury bug has taken a bite out of some teams in Week 2, with Washington Commanders running back Austin Ekeler going down with an Achilles injury on Thursday night, along with Green Bay Packers wideout Jayden Reed breaking his collarbone.