Opioid drugs such as morphine and fentanyl produce their strong analgesic and adverse effects (in particular, respiratory depression and likelihood of abuse) by activating a G protein–coupled receptor ...

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems - prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same ...

One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the 19th century. Morphine molecules act as painkillers by attaching themselves to ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Challenging a decades-old understanding of why morphine-like drugs lose effectiveness with increased use, UCSF scientists have demonstrated in animals how morphine’s potent painkilling powers can be ...

Opioid agonists are substances that activate opioid receptors in the central and peripheral nervous systems. They have several uses, from pain management to treating opioid use disorder. You have ...

Morphine is one of the most famous natural products in the world and the progenitor of many semisynthetic opioids, such as heroin and oxycodone, as well as the overdose-reversing drug naloxone. Most ...