The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

IgG was the only class of antibodies that were actively transported from mother to offspring for a long time, and this resulted in short-term passive immunity. The specific IgG transport was realized ...

A Japanese research team has uncovered how sugar chains (glycans) modifications dynamically regulate the structure and function of human immunoglobulin G (IgG) antibodies. By integrating nuclear ...

This is a preview. Log in through your library . Abstract Idiotypy has been studied in antibodies against a protein antigen: hen ovalbumin. Various fractions of antisera to hen ovalbumin have been ...

IdeS IgG protease shows promise for Myasthenia Gravis, Immune Thrombocytopenia, and dozens of other IgG-driven autoimmune diseases. The wild type enzyme elicits potent anti-drug antibodies (ADA) that ...

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019, and ...