Scientists are exploring ways to mimic the origins of human life without two fundamental components: sperm and egg. They are coaxing clusters of stem cells – programmable cells that can transform into ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

Northwestern Medicine scientists have discovered that one of the body's most fundamental biological processes—how red blood cells are made—works differently in humans than previously thought, ...

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic ...

As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in ...

Summary: Researchers developed “Core2Edge,” an advanced ex vivo human tissue model that replicates the invasive spread and ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...

Julie E. Gough is professor of biomaterials and tissue engineering in the Department of Materials, School of Natural Sciences and NIHR Manchester Biomedical Research Centre, University of Manchester, ...

A new lipid nanoparticle platform delivers full-length antibodies inside cells, unlocking intracellular targets in cancer, autoimmune disease, and Parkinson’s.