Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Well… Welcome to the seventh edition of Loser Monday, the calling card of the 2025 Arizona Cardinals. The Suns weren’t much help last night, either.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

Bam Knight is active for the Arizona Cardinals' Week 11 game against the San Francisco 49ers and will likely lead the backfield, as he has recently.

The Arizona Cardinals announced a flurry of roster moves on Saturday to prepare for their game on Sunday against the San Francisco 49ers. They placed linebacker Mack Wilson, who missed one game already with a rib injury, on injured reserve, which puts him out of commission for at least four more games.

The Cardinals have now lost seven of their last eight, including two straight blowouts to divisional opponents.