Christian McCaffrey National Football League San Francisco 49ers Top Plays NFL - San Francisco 49ers vs. Arizona Cardinals - 11/16/2025

Check out the San Francisco 49ers biggest moments and game-changing plays from their Week 11 win over the Arizona Cardinals.

The "49ers Postgame Live" crew highlights running back Christian McCaffrey after San Francisco's 41-22 win over the Arizona Cardinals on Sunday.Christian McCaffrey totals 121 yards, three TDs in 49ers' big win vs.

Brock Purdy hit George Kittle for 30-yard TD, extending the San Francisco 49ers lead over the Arizona Cardinals.

San Francisco 49ers WR Skyy Moore sped past the Cardinals coverage unit with a 98-yard kickoff return to open the Week 11 matchup.

The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs to be.

San Francisco 49ers quarterback Brock Purdy returns to action and his first completion goes for a 25-yard gain to wide receiver Jauan Jennings against the Arizona Cardinals.

The San Francisco 49ers and Carolina Panthers are in a race for a playoff spot, but the 49ers are favored big in their Week 12 showdown on MNF.

The Arizona Cardinals‘ attempt to rebound from a divisional blowout was unsuccessful on Sunday, as they were dominated by the San Francisco 49ers to the tune of a 41-16