Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

Glendale, AZ -- The 49ers just blew out the Arizona Cardinals 41-22. Granted, the Cardinals got blown out last week too and now have lost 7 of their past 8 games since they lost to Mac Jones and the 49ers in Week 3. They're dead. They need to fire their head coach.

The NFC West’s fiercest neighbors collide tonight when the San Francisco 49ers face the Los Angeles Rams beneath the bright lights of SoFi Stadium. The 49ers bring their smashmouth swagger to a stage built for big moments, while the Rams counter with ...

The Atlanta Falcons were defeated by the San Francisco 49ers to fall to 3-3 on the season. Despite a solid effort, the Falcons made too many critical errors against a good 49ers team on the road, losing by a final score of 20-10. Atlanta committed costly penalties and failed to score when they had the chance on multiple drives.

The Vikings and 49ers are each hoping to pick up a big advantage in the NFC wild card race with a victory. I know we say this every week, but this is a big one. The Vikings are in the Bay Area to take on the 49ers in a battle of 5-5 teams hoping to gain a ...