A prime opportunity is in front of Christian McCaffrey when the San Francisco 49ers play the Los Angeles Rams in Week 10. McCaffrey can become the first player

They’ll face a Rams team that stands atop the NFC West at 6-2, coming off three straight wins over the Baltimore Ravens, Jacksonville Jaguars, and the New Orleans Saints. All three of those victories have come by at least 14 points, with Los Angeles eclipsing the 30-point mark in the last two.

Preview the Week 10 matchup between the Los Angeles Rams and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

The Los Angeles Rams face the San Francisco 49ers in an NFL game on Sunday, Nov. 9, 2025 at Levi’s Stadium in Santa Clara, California.

The Los Angeles Rams and San Francisco 49ers will meet on Sunday, and Sean McVay's team is calling up two players from the practice squad.

The Week 10 NFL schedule is another chance to to use BetMGM bonus code CBSSPORTS to receive up to $1,500 in bonus bets back if your first qualifying wager loses or $150 in bonus bets if your first $10 wager wins.

The rivalry takes on added meaning with the Rams, who have won three in a row since losing to the Niners in Week 5, needing to win to stay atop the division.

Preview the San Francisco 49ers' NFL week 10 matchup with the Rams, including betting odds, tips, trends, and game information.