The No. 21 Iowa Hawkeyes, led by quarterback Mark Gronowski, face the No. 17 USC Trojans, led by quarterback Jayden Maiava on Saturday, Nov. 15, 2025 at Los Angeles Memorial Coliseum in Los Angeles, Calif.

The Hawkeyes' offense nearly pulled off another late-game drive, but it was a third-quarter sequence that really was costly in a loss at USC.

What channel is Iowa football vs. USC on today? Here's how to watch, with start time, TV schedule, live streaming and game odds.

The No. 17 ranked USC Trojans face the No. 21 Iowa Hawkeyes hoping to avoid an upset at home in this intriguing Big Ten showdown between Top ranked 25 foes.

Iowa football takes on USC in Week 12 of the 2025 college football season. Here are the betting odds and game predictions from experts.

USC earns it spot with the best of the best in the Big Ten after its win versus Iowa, while the rest of the Big Ten stays put

The model is also backing Iowa (+6.5) to cover the spread on the road against USC, while the Over (52.5) hits 58% of the time in TCU vs. BYU. Before locking in your Week 12 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.

What went well for the Trojans on Saturday, and where did they struggle? Here are some positives and negatives from the game:

Some of the numbers don't stand out. He's made a few mistakes. Yet, there's a real case to make that Jayden Maiava is the best QB in college football